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1: J Urol. 2003 Aug;170(2 Pt 1):393-6.

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Thiazide does not affect urine oxalate excretion.

Parks JH, Coe FL.

Nephrology Section, University of Chicago, Illinois 60637, USA.

PURPOSE: We assessed the effects of thiazide treatment on urine oxalate excretion in patients with kidney stones. MATERIALS AND METHODS: Of 537 patients (231 women), 209 (81 women) received thiazide for stone prevention. Urine oxalate was measured in 3, 24-hour urines before treatment, and in 1, 24-hour urine after 6 to 12 weeks of treatment. This was an observational cohort and treatment was not randomized. RESULTS: Urine oxalate increased in general. There was no difference in increase with or without thiazide, whether one considered simple t test comparisons or used ANOVA with pretreatment oxalate excretion as a covariate. CONCLUSIONS: Thiazide administration exerts no measurable effect on urine oxalate excretion that can be detected in clinical practice.

Publication Types:

• Clinical Trial

PMID: 12853783 [PubMed - indexed for MEDLINE]

Dec 11 2003 12:53:39